BK virus-specific immunity kinetics: a predictor of recovery from polyomavirus BK-associated nephropathy.

摘要: Impaired BKV-specific immunity is associated with development of BKV-associated nephropathy. Suitable immunological parameters to identify patients at risk, however, are still debated. We monitored 18 kidney-transplant recipients through the course self-limited BKV-reactivation (n = 11) and nephropathy 7). cellular directed nonstructural small Large T-antigen, structural VP1-3 was analyzed in an interferon-γ Elispot assay. IgM IgG were measured using enzyme-linked immunosorbent assay simultaneously. five BKV-proteins increased significantly from diagnosis resolution (p < 0.001). Patients developed T cells without therapeutic interventions, cleared within a median period 1 month. nephropathy, showed after 5 months interventions only, 8 months. Anti-structural detected earlier than anti-nonstructural cells, which coincided BKV-clearance. highest frequencies recovery, increase persistence levels 0.05). Our results suggest prognostic values immune monitoring those risk aid management interventions.