BK Virus Nephropathy in Kidney Transplantation: An Approach Proposal and Update on Risk Factors, Diagnosis, and Treatment.
作者： S. Gonzalez , D.P. Escobar-Serna , O. Suarez , X. Benavides , J.F. Escobar-Serna
DOI: 10.1016/J.TRANSPROCEED.2015.05.010
关键词:
摘要: BK virus belongs to Polyomaviridae family; it causes 95% of nephropathy cases related polyomavirus, with the other 5% caused by JC virus. Nephropathy jeopardizes graft function, causing a premature failure in 1%-10% patients kidney transplants. Nowadays, antiviral effective treatment is unknown, which why blood and urine screening renal transplantation has become most important recommendation guide decrease immunosuppression, only proven method poor outcomes. Different interventions, such as cidofovir, leflunomide, fluoroquinolones, intravenous immunoglobulin, have been attempted no improvement at all. This review aims summarize relevant features virus, historical issues, transmission mechanisms, risk factors, therapeutic interventions.
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transplantation-proceedings.org 参考文章(120)
Mehsati Herawi, Anil V. Parwani, Theresa Chan, Syed Z. Ali, Jonathan I. Epstein, Polyoma virus-associated cellular changes in the urine and bladder biopsy samples: a cytohistologic correlation The American Journal of Surgical Pathology. ,vol. 30, pp. 345- 350 ,(2006) , 10.1097/01.PAS.0000179117.38787.57
S. Schaub, H. H. Hirsch, M. Dickenmann, J. Steiger, M. J. Mihatsch, H. Hopfer, M. Mayr, Reducing Immunosuppression Preserves Allograft Function in Presumptive and Definitive Polyomavirus‐Associated Nephropathy American Journal of Transplantation. ,vol. 10, pp. 2615- 2623 ,(2010) , 10.1111/J.1600-6143.2010.03310.X
H. M. Wadei, A. D. Rule, M. Lewin, A. S. Mahale, H. A. Khamash, T. R. Schwab, J. M. Gloor, S. C. Textor, M. E. Fidler, D. J. Lager, T. S. Larson, M. D. Stegall, F. G. Cosio, M. D. Griffin, Kidney transplant function and histological clearance of virus following diagnosis of polyomavirus-associated nephropathy (PVAN). American Journal of Transplantation. ,vol. 6, pp. 1025- 1032 ,(2006) , 10.1111/J.1600-6143.2006.01296.X
T. Schachtner, K. Müller, M. Stein, C. Diezemann, A. Sefrin, N. Babel, P. Reinke, BK virus-specific immunity kinetics: a predictor of recovery from polyomavirus BK-associated nephropathy. American Journal of Transplantation. ,vol. 11, pp. 2443- 2452 ,(2011) , 10.1111/J.1600-6143.2011.03693.X
C Polo, JL Perez, A Mielnichuck, CG Fedele, J Niubo, A Tenorio, Prevalence and patterns of polyomavirus urinary excretion in immunocompetent adults and children. Clinical Microbiology and Infection. ,vol. 10, pp. 640- 644 ,(2004) , 10.1111/J.1469-0691.2004.00882.X
H. H. Hirsch, P. Randhawa, , BK polyomavirus in solid organ transplantation. American Journal of Transplantation. ,vol. 13, pp. 179- 188 ,(2013) , 10.1111/AJT.12110
H. H. Hirsch, F. Vincenti, S. Friman, M. Tuncer, F. Citterio, A. Wiecek, E. H. Scheuermann, M. Klinger, G. Russ, M. D. Pescovitz, H. Prestele, Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine: a prospective, randomized, multicenter study American Journal of Transplantation. ,vol. 13, pp. 136- 145 ,(2013) , 10.1111/J.1600-6143.2012.04320.X
O. Suarez, M. Pardo, S. Gonzalez, D.P. Escobar-Serna, D.A. Castaneda, D. Rodriguez, J.C. Osorio, E. Lozano, Diabetes Mellitus and Renal Transplantation in Adults: Is There Enough Evidence for Diagnosis, Treatment, and Prevention of New-Onset Diabetes After Renal Transplantation? Transplantation Proceedings. ,vol. 46, pp. 3015- 3020 ,(2014) , 10.1016/J.TRANSPROCEED.2014.07.011
Éva Kemény, Hans H. Hirsch, József Eller, Ursula Dürmüller, Helmut Hopfer, Michael J. Mihatsch, Plasma cell infiltrates in polyomavirus nephropathy Transplant International. ,vol. 23, pp. 397- 406 ,(2010) , 10.1111/J.1432-2277.2009.01001.X
Michelle A. Josephson, Daniel Gillen, Basit Javaid, Pradeep Kadambi, Shane Meehan, Preston Foster, Robert Harland, Richard J. Thistlethwaite, Marc Garfinkel, Walter Atwood, Joslynn Jordan, Molly Sadhu, Michael J. Millis, James Williams, Treatment of renal allograft polyoma BK virus infection with leflunomide. Transplantation. ,vol. 81, pp. 704- 710 ,(2006) , 10.1097/01.TP.0000181149.76113.50