Coaxial Electrospray of Curcumin-Loaded Microparticles for Sustained Drug Release
作者： Shuai Yuan , Fan Lei , Zhongfa Liu , Qingping Tong , Ting Si
DOI: 10.1371/JOURNAL.PONE.0132609
关键词: Drug Liberation 、 Materials science 、 PLGA 、 Curcumin 、 Chemical engineering 、 Coaxial 、 Cell-Derived Microparticles 、 Solubility 、 Particle size 、 Electrospray
摘要: Curcumin exhibits superior anti-inflammatory, antiseptic and analgesic activities without significant side effects. However, clinical dissemination of this natural medicine is limited by its low solubility poor bio-availability. To overcome limitation, we propose to encapsulate curcumin in poly(lactic-co-glycolic acid) (PLGA) microparticles (MPs) an improved coaxial electrospray (CES) process. This process able generate a stable cone-jet mode wide range operation parameters order produce curcumin-loaded PLGA MPs with clear core-shell structure designated size several micrometers. In optimize the outcome, effects primary such as applied electric voltages liquid flow rates are studied systemically. vitro drug release experiments also carried out for CES-produced comparison those single axial Our experimental results show that CES can be effectively controlled drugs aqueous high encapsulation efficiency optimal profiles.
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