Nanofibrous polylactide composite scaffolds with electroactivity and sustained release capacity for tissue engineering
作者： Jing Chen , Juan Ge , Baolin Guo , Kun Gao , Peter X. Ma
DOI: 10.1039/C5TB02703A
关键词:
摘要: Nanofibrous electroactive composite scaffolds with sustained release properties based on polylactide (PLA) nanofibers and nanoparticles from polyurethane–urea copolymers were fabricated for tissue engineering applications. Electroactive into which possessed kinetics both hydrophobic hydrophilic drugs. Composite obtained using an electrospray/electrospinning procedure universally coated PLA nanofibers. The morphology of nanoparticles, fibers, was observed by SEM. drug profile studied ibuprofen rutin as model mechanism the drugs investigated. Rutin loaded material used active scaffold L929 fibroblast proliferation. Both random aligned structures nanofibrous fabricated. effect surface chemistry topographical cues C2C12 cell proliferation differentiation scaffolds, it found that electroactivity provide a synergetic myoblast differentiation. These hold great potential muscle nerve regeneration.
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