Functional implication of Dclk1 and Dclk1-expressing cells in cancer

摘要: Doublecortin like kinase protein 1 (Dclk1) is a microtubule-associated with C-terminal serine/threonine domain. Originally designated and CaM kinase-like (Dcamkl1) or KIAA0369, Dclk1 was first described as marker for radial glia cells in the context of microtubule polymerization neuronal migration, possibly contributing to early neurogenesis. Additionally, proposed quiescent gastrointestinal pancreatic stem cells, but recent years has been recognized tuft tract. While Dclk1+ are now considered niche sensory normal gut, growing evidence supports role function variety malignancies, modulating activity multiple key pathways, including Kras signaling. Here, we review advances understanding importance tumorigenesis cancer.