Immune Phenotypes of Nasopharyngeal Cancer

摘要: Nasopharyngeal cancer (NPC) features intralesional immune cells, but data are lacking on presence/distribution of T-cells and dendritic cells (DCs). Based distribution lymphocytes, a series NPC biopsies (n = 48) were classified into “inflamed”, “excluded”, “deserted” phenotypes. In addition, CD8+ CD207+ DCs quantified. The analyzed in relation to Epstein–Barr virus-encoded small RNA (EBER), Epstein-Barr virus (EBV) DNA, survival. Separately, gene expression from public database analyzed. 61.7% lesions 29.8% 8.5% “deserted”. While present cell areas surrounding stroma, observed largely areas. High T-cell presence was associated with EBV+ disease, no such pattern for DCs. There difference disease-free survival favor “inflamed” over “excluded” NPC. Gene analysis revealed differences between control tissue (e.g., regard interferon activity) as well subgroups based CD8 (high vs. low). conclusion, heterogeneous can be phenotypes that carry prognostic information. may represent target immunotherapy potential facilitate the antigen cross-presentation necessary execute cytotoxic T-lymphocyte responses.