3 Regulation of Axon Formation

摘要: A mature neuron is typically polarized with a single long axon and several dendrites. After the birth differentiation of neuron, breaks its previous symmetry establishes an Neuronal polarization occurs when one multiple immature neurites emerging from cell body elongates rapidly. This neurite becomes axon, whereas remaining become What are molecular mechanisms specifying in initial events? Here we provide overview recent progress into study formation. List Abbreviations: APC, adenomatous polyposis coli; aPKC, atypical protein kinase C; CRMP-2, collapsin responsemediator protein-2; GEF, guanine nucleotide exchange factor; GSK-3b, glycogen synthase kinase-3b; ILK, integrin-linked kinase; NgCAM, neuron-glia adhesion molecule; PI3-kinase, phosphatidylinositol 3-kinase; PIP3, 3,4,5-triphosphate; PTEN, phosphatase tensin Regulation formation homolog deleted on chromosome 10; siRNA, short interfering RNA; Sra-1, specifically Rac1-associated 1; STEF, Sifand Tiam1-like Tiam1, T-lymphoma invasion metastasis 1