Control of neuronal migration through rostral migratory stream in mice

作者: Woong Sun , Hyun Kim , Younghye Moon

DOI: 10.5115/ACB.2010.43.4.269

关键词: NeurogenesisNervous systemBiologyNeuroblastNeuroblast migrationGanglion mother cellRostral migratory streamAnatomyNeuronal migrationOlfactory bulbCell biology

摘要: During the nervous system development, immature neuroblasts have a strong potential to migrate toward their destination. In adult brain, new neurons are continuously generated in neurogenic niche located near ventricle, and newly cells actively destination, olfactory bulb, via highly specialized migratory route called rostral stream (RMS). Neuroblasts RMS form chains by homophilic interactions, continually through tunnels formed meshwork of astrocytes, glial tube. This review focuses on development structure regulation neuroblast migration RMS. Better understanding may be crucial for improving functional replacement therapy supplying endogenous neuronal injury sites more efficiently.

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