Misplacement of Purkinje Cells during Postnatal Development in Bax Knock-Out Mice: A Novel Role for Programmed Cell Death in the Nervous System?

摘要: During early postnatal development, the orchestrated regulation of proliferation, migration and survival versus elimination neurons is essential for histogenesis cerebellum. For instance, Purkinje cells (PCs) promote proliferation external granule (EGCs), whereas EGCs in turn play a role PCs. Considering that substantial number undergo programmed cell death (PCD) during cerebellar it seems likely neuronal loss could have significant To address this question, we examined development cerebellum Bax-knock-out (KO) mice which PCD PC has been reported to be selectively reduced or eliminated, are unaffected. We confirmed absence as well normal Bax-KO mice. also observed subpopulation PCs were misplaced inner layer on day 5 (P5) P10 that, by end major period (P14), lose expression marker calbindin. These results suggest removal ectopically located may previously unrecognized function developmental PCD.