The Proapoptotic Activities of Bax and Bak Limit the Size of the Neural Stem Cell Pool
作者： Tullia Lindsten , Jeffrey A. Golden , Wei-Xing Zong , Jeremy Minarcik , Marian H. Harris
DOI: 10.1523/JNEUROSCI.23-35-11112.2003
关键词: Glial Differentiation 、 Neural stem cell 、 Apoptosis 、 Programmed cell death 、 Biology 、 Cell biology
摘要: The proapoptotic Bcl-2 family members Bak and Bax play central redundant roles in the regulation of apoptosis. In this study, we investigated effect loss CNS. adult bax-/-bak-/- mice display masses densely staining cells proliferative zones brain. These are shown to be a mix neural progenitor postmitotic at different stages glial differentiation. Both mature neurons derived from were resistant various apoptotic stimuli. Despite resistance, remain as sensitive excitoxic death wild-type neurons. Thus, critical role regulating number brain but not absolutely required for initiation neuronal cell after neurotoxic injury.
sci-hub.se 参考文章(27)
Richard Dargusch, Dana Piasecki, Shirlee Tan, Yuanbin Liu, David Schubert, The role of Bax in glutamate-induced nerve cell death Journal of Neurochemistry. ,vol. 76, pp. 295- 301 ,(2008) , 10.1046/J.1471-4159.2001.00035.X
Rémy Sadoul, BCL-2 family members in the development and degenerative pathologies of the nervous system Cell Death & Differentiation. ,vol. 5, pp. 805- 815 ,(1998) , 10.1038/SJ.CDD.4400438
Michael C Wei, Wei-Xing Zong, Emily H-Y Cheng, Tullia Lindsten, Vily Panoutsakopoulou, Andrea J Ross, Kevin A Roth, Grant R MacGregor, Craig B Thompson, Stanley J Korsmeyer, Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death Science. ,vol. 292, pp. 727- 730 ,(2001) , 10.1126/SCIENCE.1059108
Thomas L Deckwerth, Jeffrey L Elliott, C.Michael Knudson, Eugene M Johnson, William D Snider, Stanley J Korsmeyer, BAX is required for neuronal death after trophic factor deprivation and during development Neuron. ,vol. 17, pp. 401- 411 ,(1996) , 10.1016/S0896-6273(00)80173-7
Bernhard Brüne, Nitric oxide: NO apoptosis or turning it ON? Cell Death & Differentiation. ,vol. 10, pp. 864- 869 ,(2003) , 10.1038/SJ.CDD.4401261
Urban Lendahl, Lyle B. Zimmerman, Ronald D.G. McKay, CNS stem cells express a new class of intermediate filament protein. Cell. ,vol. 60, pp. 585- 595 ,(1990) , 10.1016/0092-8674(90)90662-X
Maria Ankarcrona, Jeannette M. Dypbukt, Emanuela Bonfoco, Boris Zhivotovsky, Sten Orrenius, Stuart A. Lipton, Pierluigi Nicotera, Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function Neuron. ,vol. 15, pp. 961- 973 ,(1995) , 10.1016/0896-6273(95)90186-8
Mark D. Johnson, Hong Xiang, Susan London, Yoshito Kinoshita, Michael Knudson, Marc Mayberg, Stanley J. Korsmeyer, Richard S. Morrison, Evidence for involvement of Bax and p53, but not caspases, in radiation‐induced cell death of cultured postnatal hippocampal neurons Journal of Neuroscience Research. ,vol. 54, pp. 721- 733 ,(1998) , 10.1002/(SICI)1097-4547(19981215)54:6<721::AID-JNR1>3.0.CO;2-1
N. Motoyama, F. Wang, K. Roth, H. Sawa, K. Nakayama, K. Nakayama, I. Negishi, S. Senju, Q. Zhang, S. Fujii, a. et, Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice Science. ,vol. 267, pp. 1506- 1510 ,(1995) , 10.1126/SCIENCE.7878471
Gregory G. Heuer, Annette F. Skorupa, R.K. Prasad Alur, Kanli Jiang, John H. Wolfe, Accumulation of abnormal amounts of glycosaminoglycans in murine mucopolysaccharidosis type VII neural progenitor cells does not alter the growth rate or efficiency of differentiation into neurons. Molecular and Cellular Neuroscience. ,vol. 17, pp. 167- 178 ,(2001) , 10.1006/MCNE.2000.0917