Single-Nucleotide Polymorphism–Based Genetic Risk Score and Patient Age at Prostate Cancer Diagnosis
作者： Rong Na , Craig Labbate , Hongjie Yu , Zhuqing Shi , Richard J. Fantus
DOI: 10.1001/JAMANETWORKOPEN.2019.18145
关键词: Internal medicine 、 Interquartile range 、 Prostate cancer 、 Survival rate 、 Cohort study 、 P-Chloroamphetamine 、 Medicine 、 Prostate biopsy 、 Relative risk 、 Population
摘要: Importance Few studies have evaluated the association between a single-nucleotide polymorphism–based genetic risk score (GRS) and patient age at prostate cancer (PCa) diagnosis. Objectives To test GRS PCa diagnosis to compare performance of with that family history (FH) in stratification. Design, Setting, Participants A cohort study 3225 white men was conducted as secondary analysis Reduction by Dutasteride Prostate Cancer Events (REDUCE) chemoprevention trial, 4-year, randomized, double-blind, placebo-controlled multicenter from March 2003 April 2009 evaluate safety efficacy dutasteride reducing events. were confirmed be free biopsy (6-12 cores) within 6 months prior underwent 10 core biopsies every 2 years per protocol. The dates for performing data July 2016 October 2019. Interventions well-established, population-standardized calculated each participant based on 110 known risk–associated polymorphisms, which is relative compared general population. Men classified into 3 groups predetermined cutoff values: low ( Main Outcomes Measures diagnosis–free survival among different groups. Results Among (median age, 63 [interquartile range, 58-67 years]) study, 683 (21%) risk, 1937 (60%) average 605 (19%) high alone. In comparison, 2789 (86%) or 436 (14%) FH higher had rate worse than those lower group (χ2 = 53.3;P 80 years) more (95% CI, >80 risk. contrast, median 73 71-76 positive 77 76-79 negative FH. Conclusions Relevance This suggests significantly associated Combining may better stratify inherited alone developing personalized screening strategies.
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sci-hub.se 参考文章(30)
Haowen Jiang, Fang Liu, Zhong Wang, Rong Na, Limin Zhang, Yishuo Wu, Jie Zheng, Xiaoling Lin, Deke Jiang, Jielin Sun, S. Lilly Zheng, Qiang Ding, Jianfeng Xu, Prediction of prostate cancer from prostate biopsy in Chinese men using a genetic score derived from 24 prostate cancer risk-associated SNPs The Prostate. ,vol. 73, pp. 1651- 1659 ,(2013) , 10.1002/PROS.22661
Shancheng Ren, Jianfeng Xu, Tie Zhou, Haowen Jiang, Haitao Chen, Fang Liu, Rong Na, Limin Zhang, Yishuo Wu, Jielin Sun, Bo Yang, Xu Gao, S. Lilly Zheng, Chuanliang Xu, Qiang Ding, Yinghao Sun, Plateau effect of prostate cancer risk-associated SNPs in discriminating prostate biopsy outcomes. The Prostate. ,vol. 73, pp. 1824- 1835 ,(2013) , 10.1002/PROS.22721
S. Lilly Zheng, Jielin Sun, Fredrik Wiklund, Shelly Smith, Pär Stattin, Ge Li, Hans-Olov Adami, Fang-Chi Hsu, Yi Zhu, Katarina Bälter, A. Karim Kader, Aubrey R. Turner, Wennuan Liu, Eugene R. Bleecker, Deborah A. Meyers, David Duggan, John D. Carpten, Bao-Li Chang, William B. Isaacs, Jianfeng Xu, Henrik Grönberg, Cumulative Association of Five Genetic Variants with Prostate Cancer The New England Journal of Medicine. ,vol. 358, pp. 910- 919 ,(2008) , 10.1056/NEJMOA075819
Nasim Mavaddat, Paul DP Pharoah, Kyriaki Michailidou, Jonathan Tyrer, Mark N Brook, Manjeet K Bolla, Qin Wang, Joe Dennis, Alison M Dunning, Mitul Shah, Robert Luben, Judith Brown, Stig E Bojesen, Børge G Nordestgaard, Sune F Nielsen, Henrik Flyger, Kamila Czene, Hatef Darabi, Mikael Eriksson, Julian Peto, Isabel dos-Santos-Silva, Frank Dudbridge, Nichola Johnson, Marjanka K Schmidt, Annegien Broeks, Senno Verhoef, Emiel J Rutgers, Anthony Swerdlow, Alan Ashworth, Nick Orr, Minouk J Schoemaker, Jonine Figueroa, Stephen J Chanock, Louise Brinton, Jolanta Lissowska, Fergus J Couch, Janet E Olson, Celine Vachon, Vernon S Pankratz, Diether Lambrechts, Hans Wildiers, Chantal Van Ongeval, Erik Van Limbergen, Vessela Kristensen, Grethe Grenaker Alnæs, Silje Nord, Anne-Lise Borresen-Dale, Heli Nevanlinna, Taru A Muranen, Kristiina Aittomäki, Carl Blomqvist, Jenny Chang-Claude, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Peter A Fasching, Lothar Haeberle, Arif B Ekici, Matthias W Beckmann, Barbara Burwinkel, Frederik Marme, Andreas Schneeweiss, Christof Sohn, Amy Trentham-Dietz, Polly Newcomb, Linda Titus, Kathleen M Egan, David J Hunter, Sara Lindstrom, Rulla M Tamimi, Peter Kraft, Nazneen Rahman, Clare Turnbull, Anthony Renwick, Sheila Seal, Jingmei Li, Jianjun Liu, Keith Humphreys, Javier Benitez, M Pilar Zamora, Jose Ignacio Arias Perez, Primitiva Menendez, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Natalia V Bogdanova, Natalia N Antonenkova, Thilo Dörk, Hoda Anton-Culver, Susan L Neuhausen, Argyrios Ziogas, Leslie Bernstein, Peter Devilee, Robert AEM Tollenaar, Caroline Seynaeve, Christi J Van Asperen, Angela Cox, Simon S Cross, Malcolm WR Reed, Elza Khusnutdinova, Marina Bermisheva, Darya Prokofyeva, Zalina Takhirova, Alfons Meindl, Rita K Schmutzler, Christian Sutter, Rongxi Yang, Peter Schürmann, Michael Bremer, Hans Christiansen, Tjoung-Won Park-Simon, Peter Hillemanns, Pascal Guénel, Thérèse Truong, Florence Menegaux, Marie Sanchez, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Valeria Pensotti, John L Hopper, Helen Tsimiklis, Carmel Apicella, Melissa C Southey, Hiltrud Brauch, Thomas Brüning, Yon-Dschun Ko, Alice J Sigurdson, Michele M Doody, Ute Hamann, Diana Torres, Hans-Ulrich Ulmer, Asta Försti, Elinor J Sawyer, Ian Tomlinson, Michael J Kerin, Nicola Miller, Irene L Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Georgia Chenevix-Trench, Rosemary Balleine, Graham G Giles, Roger L Milne, Catriona McLean, Annika Lindblom, Sara Margolin, Christopher A Haiman, None, Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants Journal of the National Cancer Institute. ,vol. 107, pp. 036- 036 ,(2015) , 10.1093/JNCI/DJV036
A. Karim Kader, Jielin Sun, Brian H. Reck, Paul J. Newcombe, Seong-Tae Kim, Fang-Chi Hsu, Ralph B. D’Agostino, Sha Tao, Zheng Zhang, Aubrey R. Turner, Greg T. Platek, Colin F. Spraggs, John C. Whittaker, Brian R. Lane, William B. Isaacs, Deborah A. Meyers, Eugene R. Bleecker, Frank M. Torti, Jeffery M. Trent, John D. McConnell, S. Lilly Zheng, Lynn D. Condreay, Roger S. Rittmaster, Jianfeng Xu, Potential impact of adding genetic markers to clinical parameters in predicting prostate biopsy outcomes in men following an initial negative biopsy: findings from the REDUCE trial. European Urology. ,vol. 62, pp. 953- 961 ,(2012) , 10.1016/J.EURURO.2012.05.006
H. Ballentine Carter, Peter C. Albertsen, Michael J. Barry, Ruth Etzioni, Stephen J. Freedland, Kirsten Lynn Greene, Lars Holmberg, Philip Kantoff, Badrinath R. Konety, Mohammad Hassan Murad, David F. Penson, Anthony L. Zietman, Early Detection of Prostate Cancer: AUA Guideline Journal of Urology. ,vol. 190, pp. 419- 426 ,(2013) , 10.1016/J.JURO.2013.04.119
, A global reference for human genetic variation. Nature. ,vol. 526, pp. 68- 74 ,(2015) , 10.1038/NATURE15393
G. A. Thorisson, The International HapMap Project Web site web science. ,vol. 15, pp. 1592- 1593 ,(2005) , 10.1101/GR.4413105
[...] ERSPC Investigators Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Zappa M, Nelen V, Kwiatkowski M, Lujan M, Määttänen L, Lilja H, Denis LJ, Recker F, Paez A, Bangma CH, Carlsson S, Puliti D, Villers A, Rebillard X, Hakama M, None, Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up The Lancet. ,vol. 384, pp. 2027- 2035 ,(2014) , 10.1016/S0140-6736(14)60525-0
J Athene Lane, Jenny L Donovan, Michael Davis, Eleanor Walsh, Daniel Dedman, Liz Down, Emma L Turner, Malcolm D Mason, Chris Metcalfe, Tim J Peters, Richard M Martin, David E Neal, Freddie C Hamdy, Active monitoring, radical prostatectomy, or radiotherapy for localised prostate cancer: study design and diagnostic and baseline results of the ProtecT randomised phase 3 trial Lancet Oncology. ,vol. 15, pp. 1109- 1118 ,(2014) , 10.1016/S1470-2045(14)70361-4