Effects of Intrathecal Flecainide for Pain Behavior in Formalin Test and Hemodynamics in Rat

摘要: Background: The antinociceptive activity of drugs with a sodium channel blocker is an anti-arrhythmic agent belonging to the Ie class. Although effects flecainide have been demonstrated in few animal pain models and clinical trials, its role nociceptive transmission at spinal level has not evaluated. purpose this study was evaluate intrathecal on nociception hemodynamics. Methods: Flecainide administered via catheter. formalin test used as model, which induced by subcutaneous injection solution (5%, 50) into rats' hind paw. blood pressure heart rate were measured using intra-arterial catheter tail artery. Results: Intrathecal prior reduced behavior dose-dependent fashion during both phases 1 2. In contrast, after intrathecally-administered did affect phase 2 highest dose. addition, produces no significant effect resting or rate. Conclusions: attenuated when before, but injection, caused hemodynamic changes.