Mazindol and lidocaine are antinociceptives in the mouse formalin model: involvement of dopamine receptor

摘要: The antinociceptive potential of mazindol, an anorectic drug, and lidocaine, amide-type local anesthetic, were investigated in the mouse formalin test with concurrent motor function assessment. In addition, role dopamine opioid receptors mediation action these drugs was examined. i.p. injection mazindol (1.25–10 mg/kg) lidocaine (10–30 induced significant responses both phases test. Cocaine (20 mg/kg, i.p.), used as positive control, also inhibited pain caused by formalin. Haloperidol (0.2 sulpiride (5 a D2 receptor antagonist, reduced actions cocaine, while SCH 23390, R(+)-7-chloro 8-hydroxy-3methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3 benzazepine (0.03 D1 did not affect responses. Only antinociception associated reversed naloxone (2 i.p.). same pretreatments failed to modify lidocaine-induced antinociception. drug conditions this study reveal any impairment rotarod These observations suggest involvement dopaminergic mechanisms, mainly via receptors, test, but nature mechanisms involved remains unsolved.