Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis.

摘要: Since the highly conserved exosome complex mediates degradation and processing of multiple classes RNAs, it almost certainly controls diverse biological processes. How this post-transcriptional RNA-regulatory machine impacts cell fate decisions differentiation is poorly understood. Previously, we demonstrated that subunits confer an erythroid maturation barricade, transcription factor GATA-1 dismantles barricade by transcriptionally repressing cognate genes. While dissecting requirements for in Mus musculus, discovered a vital determinant developmental signaling transition dictates proliferation/amplification versus differentiation. Exosome integrity precursor cells ensures Kit receptor tyrosine kinase expression stem factor/Kit signaling, while preventing responsiveness to erythropoietin-instigated signals promote Functioning as gatekeeper transition, massive production organismal survival homeostatic stress contexts.