Oxidative stress as a cause of Parkinson's disease.

摘要: The cause of dopamine cell death in Parkinson's disease remains unknown. Present interest centres on the possible involvement a toxin mediated mechanism such as that produced, by MPTP. In post-mortem studies there is evidence substantia nigra for an on-going toxic process involving increased lipid peroxidation, altered iron metabolism and impairment mitochondrial function at level complex I. Although precise realtionship between these biochemical changes not known, present points to oxidative stress important factor contributing neuronal loss. Altered levels may initiate but rather act accelerate death. Future strategies treatment should be aimed preventing stopping or slowing progression underlying pathology.