Chapter 13a. Human Antiparasitic Agents
作者： Alexander R. Surrey , Allen Yarinsky
DOI: 10.1016/S0065-7743(08)61317-2
关键词: Chloroquine 、 Mechanism of action 、 Plasmodium falciparum 、 Pharmacology 、 Malaria 、 Quinine 、 Drug 、 Antiparasitic agent 、 Pyrimethamine 、 Biology
摘要: Publisher Summary This chapter describes various aspects of human antiparasitic agents. The 4-aminoquinoline resistant Plasmodium falciparum malaria is an important problem in specific areas. Effective treatment with combinations two or more antimalarials including chloroquine, colchicine, quinine, pyrimethamine long-acting sulfonamides, and diaminodiphenylsulfone (DDS) has been reported. A review the mechanism action chloroquine presented chapter. drug interferes several enzymes, binds to melanin DNA, stabilizes lysosomes, blocks sulfhydryldisulfide interchange reaction. In presence chloroquine-sensitive plasmodia, mouse erythrocytes concentrate levels than twice as high those parasitized by chloroquine-resistant plasmodia. Cyclization derivatives arylbiguanides arylamidineureas acetoacetic ester acetylacetone corresponding pyrimidines reduced both toxicity anti-malarial activity. compounds resulting from coupling sulfa drugs showed antimalarial activity, which appears be due intact molecule.
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