Local reaction and migration of injected silicone gel: Experimental study

作者: Cassio Menezes Raposo do Amaral , Valdenize Tiziani , Maria Leticia Cintra , Ingrid Amstalden , Fortunato Badan Palhares

DOI: 10.1007/BF00437108

关键词: ImplantAnatomyGiant cellSiliconeStomachMedicinePancreasFibrosisPlastic surgerySpleenPathologySurgery

摘要: A study of the local and migratory effects free silicone gel taken from a mammary prosthesis is reported. Thirty eight Wistar rats were injected in their subcutaneous space with 1 cm3 gel. The animals sacrificed on day: 3, 7, 15, 30, 60, 180, 240, 360, 420, 450. visceral organs (heart, kidneys, lungs, stomach, gonads, liver, pancreas, spleen, intestine), as well tissue adjacent to region injection, histologically analyzed. There was no detectable damage based routine histopathological analysis. greatest fibrosis observed at extremities disk formed by space.

参考文章(23)
JORGE M. ANDREWS, Cellular behavior to injected silicone fluid: a preliminary report. Plastic and Reconstructive Surgery. ,vol. 38, pp. 581- 583 ,(1966) , 10.1097/00006534-196638060-00017
THOMAS D. REES, JOAN PLATT, DONALD L. BALLANTYNE, AN INVESTIGATION OF CUTANEOUS RESPONSE TO DIMETHYLPOLYSILOXANE (SILICONE LIQUID) IN ANIMALS AND HUMANS--A PRELIMINARY REPORT. Plastic and Reconstructive Surgery. ,vol. 35, pp. 131- 139 ,(1965) , 10.1097/00006534-196502000-00002
William M. Cocke, H. Wayne Sampson, John M. Quarles, Observations of cell function and morphology in the presence of silicone gel: an in vitro study. Annals of Plastic Surgery. ,vol. 19, pp. 406- 408 ,(1987) , 10.1097/00000637-198711000-00003
Charles A. Vinnik, Suction lipoplasty of silicone-injected breasts: a warning. Plastic and Reconstructive Surgery. ,vol. 83, pp. 926- ,(1989) , 10.1097/00006534-198905000-00048
DONALD L. BALLANTYNE, THOMAS D. REES, IRVING SEIDMAN, Silicone fluid: response to massive subcutaneous injections of dimethylpolysiloxane fluid in animals. Plastic and Reconstructive Surgery. ,vol. 36, pp. 330- 338 ,(1965) , 10.1097/00006534-196509000-00005
Carson M. Lewis, Inflammatory carcinoma of the breast following silicone injections. Plastic and Reconstructive Surgery. ,vol. 66, pp. 134- 136 ,(1980) , 10.1097/00006534-198007000-00026
LARS M. VISTNES, JAMES W. BENTLEY, DAVID C. FOGARTY, Experimental study of tissue response to ruptured gel-filled mammary prostheses. Plastic and Reconstructive Surgery. ,vol. 59, pp. 31- 34 ,(1977) , 10.1097/00006534-197701000-00005
THOMAS D. REES, DONALD L. BALLANTYNE, IRVING SEIDMAN, GAIL A. HAWTHORNE, Visceral response to subcutaneous and intraperitoneal injections of silicone in mice. Plastic and Reconstructive Surgery. ,vol. 39, pp. 402- 410 ,(1967) , 10.1097/00006534-196704000-00011
NAHUM BEN-HUR, DONALD L BALLANTYNE, THOMAS D. REES, IRVING SEIDMAN, Local and systemic effects of dimethylpolysiloxane fluid in mice. Plastic and Reconstructive Surgery. ,vol. 39, pp. 423- 426 ,(1967) , 10.1097/00006534-196704000-00014