Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks.

摘要: The four mammalian phosphatidylinositol 4-kinases modulate inter-organelle lipid trafficking, phosphoinositide signalling and intracellular vesicle trafficking. In addition to catalytic domains required for the synthesis of PI4P, also contain isoform-specific structural motifs that mediate interactions with proteins such as AP-3 E3 ubiquitin ligase Itch, differences determine roles in membrane Moreover, different permutations 4-kinase isozymes may be a single cellular function occurs during distinct stages GPCR Golgi lysosome Phosphatidylinositol have recently been implicated human disease. Emerging paradigms include increased expression some cancers, impaired functioning associated neurological pathologies, subversion PI4P trafficking functions bacterial infection activation kinase activity viral We discuss how diverse sometimes overlapping present challenges design inhibitors therapeutic context.