In vitro evaluation of arylsubstituted imidazoles derivatives as antiprotozoal agents and docking studies on sterol 14α-demethylase (CYP51) from Trypanosoma cruzi, Leishmania infantum, and Trypanosoma brucei.
作者： Julio Alberto Rojas Vargas , América García López , Yulier Pérez , Paul Cos , Matheus Froeyen
DOI: 10.1007/S00436-019-06206-Z
关键词: Trypanosoma brucei 、 Trypanosoma brucei rhodesiense 、 Trypanosoma cruzi 、 Antiparasitic 、 Docking (molecular) 、 Leishmania infantum 、 Biology 、 Chagas disease 、 Biochemistry 、 Antiprotozoal
摘要: … In the present work, the synthesis of 14 arylsubstituted imidazoles and its molecular docking onto sterol 14α-demethylase (CYP51) was executed. In addition, the compounds, …
springer.com
sci-hub.se 
kuleuven.be 参考文章(30)
M F Sanner, Python: a programming language for software integration and development. Journal of Molecular Graphics & Modelling. ,vol. 17, pp. 57- 61 ,(1999)
Laura Friggeri, Tatiana Y. Hargrove, Girish Rachakonda, Amanda D. Williams, Zdzislaw Wawrzak, Roberto Di Santo, Daniela De Vita, Michael R. Waterman, Silvano Tortorella, Fernando Villalta, Galina I. Lepesheva, Structural basis for rational design of inhibitors targeting Trypanosoma cruzi sterol 14α-demethylase: two regions of the enzyme molecule potentiate its inhibition. Journal of Medicinal Chemistry. ,vol. 57, pp. 6704- 6717 ,(2014) , 10.1021/JM500739F
Paul A. Bates, Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies International Journal for Parasitology. ,vol. 37, pp. 1097- 1106 ,(2007) , 10.1016/J.IJPARA.2007.04.003
Michel Tshodi Ehata, Adelard Mbenza Phuati, Stanislas Nsaka Lumpu, Cyprien Kikweta Munduki, Donatien Bakana Phongi, Gaston Tona Lutete, Oscar Kambu Kabangu, Richard Cimanga Kanyanga, Ann Matheeussen, Paul Cos, Sandra Apers, Luc Pieters, Louis Maes, Arnold J. Vlietinck, In Vitro Antiprotozoal and Cytotoxic Activity of the Aqueous Extract, the 80% Methanol Extract and Its Fractions from the Seeds of Brucea sumatrana Roxb. (Simaroubaceae) Growing in Democratic Republic of Congo Chinese Medicine. ,vol. 3, pp. 65- 71 ,(2012) , 10.4236/CM.2012.31011
C.W. Roberts, R. McLeod, D.W. Rice, M. Ginger, M.L. Chance, L.J. Goad, Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa Molecular and Biochemical Parasitology. ,vol. 126, pp. 129- 142 ,(2003) , 10.1016/S0166-6851(02)00280-3
Tatiana Y. Hargrove, Zdzislaw Wawrzak, Jialin Liu, W. David Nes, Michael R. Waterman, Galina I. Lepesheva, Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum Journal of Biological Chemistry. ,vol. 286, pp. 26838- 26848 ,(2011) , 10.1074/JBC.M111.237099
Johann Gasteiger, Mario Marsili, ITERATIVE PARTIAL EQUALIZATION OF ORBITAL ELECTRONEGATIVITY – A RAPID ACCESS TO ATOMIC CHARGES Tetrahedron. ,vol. 36, pp. 3219- 3228 ,(1980) , 10.1016/0040-4020(80)80168-2
David A. Evans, History of the Harvard ChemDraw Project Angewandte Chemie. ,vol. 53, pp. 11140- 11145 ,(2014) , 10.1002/ANIE.201405820
Alejandro Speck Planche, Marcus Tulius Scotti, América García López, Vicente de Paulo Emerenciano, Enrique Molina Pérez, Eugenio Uriarte, Design of novel antituberculosis compounds using graph-theoretical and substructural approaches. Molecular Diversity. ,vol. 13, pp. 445- 458 ,(2009) , 10.1007/S11030-009-9129-9
Jun Yong Choi, Claudia M Calvet, Shamila S Gunatilleke, Claudia Ruiz, Michael D Cameron, James H McKerrow, Larissa M Podust, William R Roush, None, Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents. Journal of Medicinal Chemistry. ,vol. 56, pp. 7651- 7668 ,(2013) , 10.1021/JM401067S