In Vitro Antiprotozoal and Cytotoxic Activity of the Aqueous Extract, the 80% Methanol Extract and Its Fractions from the Seeds of Brucea sumatrana Roxb. (Simaroubaceae) Growing in Democratic Republic of Congo
作者： Michel Tshodi Ehata , Adelard Mbenza Phuati , Stanislas Nsaka Lumpu , Cyprien Kikweta Munduki , Donatien Bakana Phongi
关键词: Antiprotozoal 、 Simaroubaceae 、 Chloroquine 、 Alkaloid 、 Traditional medicine 、 IC50 、 Brucea 、 Strain (chemistry) 、 Biochemistry 、 Leishmania infantum 、 Biology
摘要: The in vitro antiprotozoal and cytotoxic activity of the aqueous extract, 80% methanol its different soluble fractions subfractions from Brucea sumatrana seeds were assessed against two Trypanosoma (T. cruzi T. brucei brucei), Leishmania infantum chloroquine pyrimethanine-resistant K1strain P. falciparum MRC-5 cell-lines respectively. Results indicated that extract showed a effect cell lines with CC50 value 0.54 μg/ml. It however exhibited pronounced non selective (IC50 = 1.52 μg/ml, SI 0.03) L. 2.41 0.22). displayed 2.16) pyrimethamine-resistant K1 strain 2.16). All partition found to exhibit an IC50 values ranging T .cruzi, b. brucei, 0.33, 81, 81 >81 chloroform fraction rich alkaloid was (CC50 27.09 μg/ml) good 8.36 3.24) moderate cruzi, chloroquine-pyrimethane-resistant (20 50 1.55 0.43 μg/ml respectively), they (SI >6.2 >1.72 respectively). These extracts low respectively 24.05 6.82
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