Minoxidil attenuates ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes.

作者: Tomoka Takatani , Kyoko Takahashi , Chengshi Jin , Takahisa Matsuda , Xinyao Cheng

DOI: 10.1097/00005344-200406000-00008

关键词: MedicineMinoxidilNeonatal ratIschemiaSimulated ischemiaInternal medicineEndocrinologyApoptosisNecrosis

摘要: Abstract:The effects of minoxidil (a mitochondrial K+ATP channel opener) on ischemia-induced necrosis and apoptosis were examined using a cardiomyocyte model simulated ischemia, since mito-chondrial openers have been suggested to be involved in the mechanisms cardioprotective act

参考文章(39)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
M Horie, Y Okada, S Hayashi, Ionic mechanism of minoxidil sulfate-induced shortening of action potential durations in guinea pig ventricular myocytes. Journal of Pharmacology and Experimental Therapeutics. ,vol. 265, pp. 1527- 1533 ,(1993)
Camillo Peracchia, Xiao G. Wang, Lillian L. Peracchia, Is the chemical gate of connexins voltage sensitive? Behavior of Cx32 wild-type and mutant channels. American Journal of Physiology-cell Physiology. ,vol. 276, ,(1999) , 10.1152/AJPCELL.1999.276.6.C1361
Lachgar, Charveron, Gall, Bonafe, Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells British Journal of Dermatology. ,vol. 138, pp. 407- 411 ,(1998) , 10.1046/J.1365-2133.1998.02115.X
John P Veinot, Deborah A Gattinger, Henry Fliss, Early apoptosis in human myocardial infarcts. Human Pathology. ,vol. 28, pp. 485- 492 ,(1997) , 10.1016/S0046-8177(97)90039-3
Antti Saraste, Kari Pulkki, Markku Kallajoki, Kenth Henriksen, Martti Parvinen, Liisa-Maria Voipio-Pulkki, Apoptosis in Human Acute Myocardial Infarction Circulation. ,vol. 95, pp. 320- 323 ,(1997) , 10.1161/01.CIR.95.2.320
H.J. Dargie, C.T. Dollery, J. Daniel, MINOXIDIL IN RESISTANT HYPERTENSION The Lancet. ,vol. 310, pp. 515- 518 ,(1977) , 10.1016/S0140-6736(77)90660-2
Toshiaki Sato, Norihito Sasaki, Jegatheesan Seharaseyon, Brian O’Rourke, Eduardo Marbán, Selective pharmacological agents implicate mitochondrial but not sarcolemmal K(ATP) channels in ischemic cardioprotection. Circulation. ,vol. 101, pp. 2418- 2423 ,(2000) , 10.1161/01.CIR.101.20.2418
Carol Ann Remme, Cees A. Schumacher, Jan W. J. de Jong, Jan W. T. Fiolet, Joris R. de Groot, Ruben Coronel, Arthur A. M. Wilde, K(ATP) channel opening during ischemia: effects on myocardial noradrenaline release and ventricular arrhythmias Journal of Cardiovascular Pharmacology. ,vol. 38, pp. 406- 416 ,(2001) , 10.1097/00005344-200109000-00009
Allen E Buhl, Daniel J Waldon, Carolyn A Baker, Garland A Johnson, Minoxidil sulfate is the active metabolite that stimulates hair follicles Journal of Investigative Dermatology. ,vol. 95, pp. 553- 557 ,(1990) , 10.1111/1523-1747.EP12504905