Method for producing benzylidene derivatives
作者： Nobuhiro Haga , Susumu Kamata , Masanao Inagaki , Saichi Matsumoto
DOI:
关键词: Base (group theory) 、 Medicinal chemistry 、 Ring (chemistry) 、 Alkyl 、 Halogen 、 Stereochemistry 、 Alkoxy group 、 Phenylene 、 Aryl 、 Chemistry
摘要: The present invention is directed to a selective method for producing given stereoisomeric benzylidene derivatives of the formula III: wherein R1 and R2 each independently lower alkyl, alkoxy or halogen; Y SO2, SO CO; -A- optionally substituted alkylene; -B- -CH2- -O-; taken together may form phenylene alkenylene; R hydrogen, cycloalkyl, alkoxy, hydroxy, aryl, arylalkyl; arylalkyloxy, heterocyclic ring N-protecting groups, which comprises reacting compound I: are as defined above X halogen with II: Y, -A-, in presence base. compounds useful non-steroidal anti-inflammatory agents.
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