Adenovirus-mediated gene therapy

作者: Seppo A I Yla-Herttuala , Anu-Maaria Sandmair , Sami A I Loimas , Matti Vapalahti

DOI:

关键词: GendicineCancer researchThymidine Kinase GeneBiologyGenetic enhancementMolecular biology

摘要: An adenovirus having a functional thymidine kinase gene is useful in the treatment of brain tumours.

参考文章(12)
Inder M Verma, Nikunj Somia, None, Gene therapy -- promises, problems and prospects Nature. ,vol. 389, pp. 239- 242 ,(1997) , 10.1038/38410
I Mottet, Jean Pierre Brion, Roger Demeure, Jean Noël Octave, A Maron, A Le Roux, J F Dedieu, M Perricaudet, T Gustin, Gene therapy of rat C6 glioma using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene: long-term follow-up by magnetic resonance imaging. Gene Therapy. ,vol. 3, pp. 315- 322 ,(1996)
Nicholas Miller, Richard Vile, Targeted vectors for gene therapy. The FASEB Journal. ,vol. 9, pp. 190- 199 ,(1995) , 10.1096/FASEBJ.9.2.7781922
M. J. Perez-Cruet, T. W. Trask, S-H. Chen, J. C. Goodman, S. L. C. Woo, R. G. Grossman, H. D. Shine, Adenovirus‐mediated gene therapy of experimental gliomas Journal of Neuroscience Research. ,vol. 39, pp. 506- 511 ,(1994) , 10.1002/JNR.490390417
Stephen L. Eck, Jane B. Alavi, Abass Alavi, Alan Davis, David Hackney, Kevin Judy, Joan Mollman, Peter C. Phillips, Eric B. Wheeldon, James M. Wilson, Treatment of Advanced CNS Malignancies with the Recombinant Adenovirus H5.010RSVTK: A Phase I Trial. University of Pennsylvania Medical Center, Philadelphia Human Gene Therapy. ,vol. 7, pp. 1465- 1482 ,(1996) , 10.1089/HUM.1996.7.12-1465
S. H. Chen, H. D. Shine, J. C. Goodman, R. G. Grossman, S. L. Woo, Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 3054- 3057 ,(1994) , 10.1073/PNAS.91.8.3054
Mahendra P Deonarain, Ligand-targeted receptor-mediated vectors for gene delivery Expert Opinion on Therapeutic Patents. ,vol. 8, pp. 53- 69 ,(1998) , 10.1517/13543776.8.1.53