Pharmacotherapy for hyperactivity in children with autism and other pervasive developmental disorders.

摘要: We reviewed pharmacological treatments used in children with autism and PDD-NOS who present hyperactive symptoms. Some 41 studies were identified from the following drug categories: antipsychotics (n = 13), serotonin reuptake inhibitors 3), antianxiety drugs 4), psychostimulants 10), alpha adrenergic agonists 2), opiate blockers 7), other 2). Empirical evidence for significant reductions symptoms was strongest antipsychotics, psychostimulants, naltrexone. Most have focused on reduction of overactivity, more emphasis needs to be placed distractibility attentional variables. A theoretical model proposed which participants' performance may predict clinical response psychostimulants. More carefully controlled comprehensive hyperactivity are badly needed these children.