Extracellular matrix destruction by invasive tumor cells

摘要: The invasion of normal tissues and penetration basement membranes by malignant cells is likely to require the active participation hydrolytic enzymes. four major groups connective tissue proteins, glycoproteins, proteoglycans, collagen elastin, vary in their quantitative distributions between different tissues. With exception they also qualitatively within each class, so that there are no ‘typical’ barriers tumor cell penetration. matrix constituents stabilized organized a variety covalent noncovalent interactions proteins. These play important roles integrity may alter susceptibilities degradative It complete degradation will action more than one enzyme because differing proteinases. Primary transplantable tumors produce well-characterized enzymes which participate invasion. be involved turnover other pathological situations. use long-term cultures has verified themselves capable producing these However, many potential modulating influences opperative vivo absent culture details actual mechanisms control digestion complex substrates not well understood. Recent work on extracellular matrices previously produced cultured shed light pathways destruction vivo. Experiments with variants defined metastatic potentials useful, but invasive abilities necessarily correlated. unlikely simple correlations can drawn production particular all biological operative during