Interaction of Tumor Cells with the Basement Membrane of Endothelium

摘要: Intense clinical and experimental interest continues to be placed on cancer invasion metastasis since these pathologic processes are widely considered the major cause of death resulting from malignant disease (1–3). In addition, properties define phenotype tumor cells Tumor with metastatic potential, which comprise only a subpopulation heterogenous within primary neoplasm, can give rise secondary colonization following numerous complex cell-host interactions (4); for example, invasive, penetrate number host extracellular matrices barriers. This chapter will review recent findings dealing interaction one particular type matrix that is encountered by invasive at several steps process: basement membrane. Following an overview structure function membranes, including vascular emphasis discrete involved in cell-basement membrane interaction: cell attachment, dissolution mediated cell-derived proteolytic enzymes subsequent locomotion through localized domains degraded proximity invading cells.