Pericellular Matrix in Malignant Transformation

摘要: Publisher Summary This chapter describes the properties of major defined matrix components, and considers their role for cell phenotype. The principal function is to give mechanical support anchor cells in tissue type-specific structures, but it may also have other duties, such as that a selective permeability barrier. composition surrounding cells, pericellular matrix, closely dependent on type degree its differentiation. It has been becoming increasingly evident altered or defective surface-matrix interactions be salient features malignant Failure maintain an intact basal lamina involved neoplastic disorganization architecture development invasive tumors. emphasizes components seem adhesion, less extracellular material. Furthermore, recent results epithelial proteolysis laminae, interstitial are characteristic some tumor discussed chapter.