Stromal involvement in malignant growth.

摘要: Publisher Summary This chapter describes various modes of interaction between malignant cells and stroma. Malignant are shown to produce lytic enzymes, which attack the stroma or induce fibroblasts synthesize collagenolytic, elastolytic, glycosaminoglycan-degrading enzymes. In some cancers tumor stimulate stromal components—collagen, elastin, glycosaminoglycans. Migration is partly determined by versatile adhesive glycoproteins in Wound healing especially fibrosis (scars) appear be possible auxiliary factors carcinogenesis. Stromal (local generalized) may exhibit subtle alterations similar transformed cells. preceding manifest malignancy contribute vitro data point intricate interdependencies cancer resulting synthesis collagenolytic Normal ontogenesis depends on a complex interactions tissues among plays an essential role. Epithelial–stromal also important adult organism. growth, microenvironmental signals constitute category influences contributing malignancy.