Hepatocyte Growth Factor and Met in Tumour Invasion-metastasis: From Mechanisms to Cancer Prevention

摘要: Hepatocyte growth factor (HGF), a ligand for c-met proto-oncogene product of receptor tyrosine kinase, exhibits powerful motogenic and angiogenic activities. The utilization the HGF-Met system in cancer cells confers invasive metastatic potentials. HGF potently enhances dissociation cells, cell-matrix interaction, extracellular matrix breakdown, invasion, angiogenesis, all critical events cascade. Tumour-stromal interaction mediated by HGF, aberrant expression Met, autocrine or mutational activation Met are tightly associated with carcinogenesis malignant progression wide variety tumours. Notably, NK4, four kringle-antagonist signaling inhibited tumour invasion metastasis. possibility has arisen that an HGF-antagonist can serve as new therapeutic strategyfor treatment patients. In normal tissues, supports dynamic tissue remodeling regeneration clinical application organ failure/fibrosis will be initiated within few years. These “two-pronged approaches” regarding lead to repair perhaps even prevention cancer.