Short and diverse route toward complex natural product-like macrocycles.
作者： Barbara Beck , Gregor Larbig , Beatrice Mejat , Marina Magnin-Lachaux , Anne Picard
DOI: 10.1021/OL034077E
关键词: Olefin fiber 、 Alkene 、 Organic chemistry 、 Carboxylic acid 、 Bifunctional 、 Chemistry 、 Natural product 、 Combinatorial chemistry 、 Metathesis 、 Macromolecule
摘要: [reaction: see text] A general strategy toward macrocyclic compounds using multicomponent reaction (MCR) chemistry, e.g., Passerini and Ugi variants, ring-closing metathesis (RCM) is introduced. The corresponding bifunctional isocyanides carboxylic acids bearing a terminal olefin are easy to prepare from the commercially available starting materials. Advantageously, this allows fast access diverse conformational space of natural product-like macrocycles could thus be interest in discovery novel bioactive agents.
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