Ionophoric effects of the antitubercular drug bedaquiline
作者： Kiel Hards , Duncan G. G. McMillan , Lici A. Schurig-Briccio , Robert B. Gennis , Holger Lill
关键词: Escherichia coli 、 Integral membrane protein 、 Biophysics 、 ATP synthase 、 Chemistry 、 Liposome 、 Transmembrane protein 、 Drug discovery 、 Bedaquiline 、 Protein subunit
摘要: Bedaquiline (BDQ), an inhibitor of the mycobacterial F 1 F o -ATP synthase, has revolutionized the antitubercular drug discovery program by defining energy metabolism as a potent …
narcis.nl参考文章(37)
Gregory M. Cook, Chris Greening, Kiel Hards, Michael Berney, Energetics of pathogenic bacteria and opportunities for drug development. Advances in Microbial Physiology. ,vol. 65, pp. 1- 62 ,(2014) , 10.1016/BS.AMPBS.2014.08.001
David G. Nicholls, Stuart J. Ferguson, ATP Synthases and Bacterial Flagella Rotary Motors Bioenergetics (Fourth Edition). pp. 197- 220 ,(2013) , 10.1016/B978-0-12-388425-1.00007-5
MARK O. WALDERHAUG, DONALD C. DOSCH, WOLFGANG EPSTEIN, Potassium Transport in Bacteria Ion Transport in Prokaryotes. pp. 85- 130 ,(1987) , 10.1016/B978-0-12-596935-2.50005-0
X Sun, K.D. Garlid, On the mechanism by which bupivacaine conducts protons across the membranes of mitochondria and liposomes. Journal of Biological Chemistry. ,vol. 267, pp. 19147- 19154 ,(1992) , 10.1016/S0021-9258(18)41754-1
David G. Nicholls, Stuart J. Ferguson, Ion transport across energy-conserving membranes Bioenergetics (Third Edition). pp. 17- 29 ,(2003) , 10.1016/B978-012518121-1/50004-X
Anna C. Haagsma, Nicole N. Driessen, Marc-Manuel Hahn, Holger Lill, Dirk Bald, ATP synthase in slow- and fast-growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction. Fems Microbiology Letters. ,vol. 313, pp. 68- 74 ,(2010) , 10.1111/J.1574-6968.2010.02123.X
Alexander Wiedenmann, Peter Dimroth, Christoph von Ballmoos, Deltapsi and DeltapH are equivalent driving forces for proton transport through isolated F(0) complexes of ATP synthases. Biochimica et Biophysica Acta. ,vol. 1777, pp. 1301- 1310 ,(2008) , 10.1016/J.BBABIO.2008.06.008
Elyse A. Dunn, Marina Roxburgh, Lesley Larsen, Robin A.J. Smith, Alexander D. McLellan, Adam Heikal, Michael P. Murphy, Gregory M. Cook, Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry. ,vol. 22, pp. 5320- 5328 ,(2014) , 10.1016/J.BMC.2014.07.050
Lubomir Hnedkovsky, Robert H. Wood, Victor N. Balashov, Electrical conductances of aqueous Na2SO4, H2SO4, and their mixtures: limiting equivalent ion conductances, dissociation constants, and speciation to 673 K and 28 MPa. Journal of Physical Chemistry B. ,vol. 109, pp. 9034- 9046 ,(2005) , 10.1021/ACS.JPCB.7B00078
Scott A. Ferguson, Stefanie Keis, Gregory M. Cook, Biochemical and Molecular Characterization of a Na+-Translocating F1Fo-ATPase from the Thermoalkaliphilic Bacterium Clostridium paradoxum Journal of Bacteriology. ,vol. 188, pp. 5045- 5054 ,(2006) , 10.1128/JB.00128-06