Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function

摘要: The nuclear factor erythroid-derived 2 (NF-E2)-related (Nrf2) is a transcription well-known for its function in controlling the basal and inducible expression of variety antioxidant detoxifying enzymes. As part cytoprotective activity, increasing evidence supports role metabolism mitochondrial bioenergetics function. Neurodegenerative diseases are excellent candidates Nrf2-targeted treatments. Most neurodegenerative conditions such as Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis, frontotemporal dementia Friedreich's ataxia characterized by oxidative stress, misfolded protein aggregates, chronic inflammation, common targets Nrf2 therapeutic strategies. Together with them, dysfunction implicated pathogenesis most disorders. recently recognized ability to regulate intermediary makes activation an attractive comprehensive strategy treatment This review aims focus on potential neurodegeneration, special emphasis function, transporters, all which collectively contribute activity this factor.