NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination.

作者: Marcus Ruscetti , Josef Leibold , Matthew J. Bott , Myles Fennell , Amanda Kulick

DOI: 10.1126/SCIENCE.AAS9090

关键词: Lung cancerKinaseProtein kinase ACytotoxicityCancer researchTumor necrosis factor alphaRetinoblastomaMAPK/ERK pathwayCellMedicine

摘要: Molecularly targeted therapies aim to obstruct cell autonomous programs required for tumor growth. We show that mitogen-activated protein kinase (MAPK) and cyclin-dependent …

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