Tumor suppression by Ink4a-Arf: progress and puzzles
作者： Scott W Lowe , Charles J Sherr
DOI: 10.1016/S0959-437X(02)00013-8
关键词: Suppressor 、 Cell growth 、 Cancer cell 、 Cancer research 、 Biology 、 Locus (genetics) 、 Apoptosis 、 Kinase 、 Transcription factor 、 Retinoblastoma protein
摘要: The two products of the Ink4a-Arf locus, p16(Ink4a) and p19(Arf) (p14(ARF) in humans), are potent tumor suppressors that regulate activities retinoblastoma protein p53 transcription factor. These proteins form part a signaling network is disrupted most, if not all, cancer cells. locus responds to stress signals, limiting cell proliferation modulating oncogene-induced apoptosis. Recent evidence emerging from mouse models distinguishes regulating onset identifies differences their responsiveness drugs.
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