Single-Dose and Steady-State Pharmacokinetics of Aminoglutethimide
作者： P. E. Lønning , J. S. Schanche , S. Kvinnsland , P. M. Ueland
DOI: 10.2165/00003088-198510040-00005
关键词: Volume of distribution 、 Urine 、 Aminoglutethimide 、 Pharmacology 、 Absorption (skin) 、 Drug 、 Equilibrium dialysis 、 Internal medicine 、 Pharmacokinetics 、 Medicine 、 Oral administration 、 Endocrinology
摘要: The oral pharmacokinetics of aminoglutethimide were determined in 17 patients receiving the drug therapeutically. absorption after intake was almost complete as judged by recovery radio-labelled urine. plasma half-life markedly reduced (mean 43%) during multiple-dose administration compared with a single dose, but only moderate increase total clearance 26.9%) observed. This finding consistent significant reduction 29.2%) apparent volume distribution (Vd) occurring prolonged treatment. These alterations could also be demonstrated drug-free interval 96 hours not explained altered protein binding aminoglutethimide, evaluated equilibrium dialysis experiments.
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