Mechanisms of Action of Aminoglutethimide as Endocrine Therapy of Breast Cancer

摘要: During the last decade aminoglutethimide has been recognised as a valuable alternative in endocrine therapy for advanced breast cancer. Although some side effects do occur, most often these are initial which subside within few weeks, and cessation of is not usually indicated. Aminoglutethimide was originally introduced an inhibitor steroidogenesis adrenal cortex. It soon recognised, however, that inhibition non-glandular aromatase, blocking conversion androgenic prohormones to oestrogens, more important, resulting decreased blood levels oestrogens. In this review role aromatase only important aspect mechanism action challenged. Evidence accumulated during years potent inducer microsomal enzymes. addition pharmacological implications (suggesting interactions), it also points possibility oestrogens due accelerated metabolism hormones. Based on new experimental data, clinical work with inhibitors, appears antitumour activity may be both This seriously challenges importance alone strategy cancer, furthermore suggests key hormones explored.