Protective effect of atorvastatin on d-galactose-induced aging model in mice

摘要: Atorvastatin (Ator), competitive inhibitors of 3-hydroxymethyl-3-glutaryl-coenzyme-A reductase, is a cholesterol lowering drug. Ator has been shown to have neuroprotective, antioxidant and anti-inflammatory properties making that potential candidate for the treatment central nervous system (CNS) disorders. Here we assessed effect on d-galactose (d-gal)-induced aging in mice. For this purpose, (0.1 1mg/kg/p.o.), was administrated daily d-gal-received (500mg/kg/p.o.) mice model six weeks. Anxiety-like behaviors cognitive functions were evaluated by elevated plus-maze novel object recognition tasks, respectively. Physical power forced swimming capacity test. Animals brains analyzed superoxide dismutase (SOD) brain-derived neurotrophic factor (BDNF). We found decreases anxiety-like d-gal-treated Also, our behavioral tests showed reverses d-gal induced learning memory impairment. Furthermore, increases physical Our results indicated neuroprotective neurotoxicity mediated, at least part, an increase SOD BDNF levels. The present study suggest could be used as therapeutic strategy age-related conditions.