Chemical Synthesis of Bioactive Naturally Derived Cyclic Peptides Containing Ene-Like Rigidifying Motifs.
作者： Luis M. De Leon Rodriguez , Elyse T. Williams , Margaret A. Brimble
关键词: Combinatorial chemistry 、 Peptide 、 Chemistry 、 Structural rigidity 、 Ene reaction 、 Cyclic peptide 、 Chemical synthesis
摘要: The development of synthetic methods to prepare conformationally constrained peptides and peptide-polyketide hybrids remain an important chemical challenge. It is known that structural rigidity correlates with the specificity, bioactivity, stability these peptide systems, thus rigid systems are particularly attractive leads for potent biopharmaceuticals. Herein we provide overview recent developments in syntheses naturally derived hybrids, a particular emphasis on those containing ene-like bond.
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