Differential expression of Notch family members in astrocytomas and medulloblastomas.
作者： Peng Xu , Shizhu Yu , Rongcai Jiang , Chunsheng Kang , Guangxiu Wang
DOI: 10.1007/S12253-009-9173-X
关键词: Notch signaling pathway 、 Notch Family 、 Tissue microarray 、 Pathology 、 Immunohistochemistry 、 Carcinogenesis 、 Western blot 、 Biology 、 Cell 、 Differential expression
摘要: Notch signaling pathway plays an integral role in determining cell fates development. Growing evidence demonstrates that has versatile effects tumorigenesis depending on the tumor type, grade and stage. is deregulated some brain tumors. To examine differential expression of family members (Notch1, 2, 3, 4) human astrocytomas medulloblastomas, to evaluate their roles development both types. Immunohistochemical staining Western blot analysis were used detect Notch1, 4 tissue microarray freshly resected samples normal brain, medulloblastomas. not expressed or barely detectable tissues. highly but Notch2 was astrocytomas. The percentage immunopositive cells level Notch1 increased with grade. In addition, overexpression detected medulloblastomas contrast low no 4. Differential may be related different playing
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