Immunohistochemical tumour markers in endometrial carcinoma.

摘要: Endometrial adenocarcinoma is the most common malignant neoplasm of female genital tract and, despite its relative frequency, molecular events that contribute to development and progression lesion remain poorly understood. The normal human endometrium characterized by hormone-dependent variations during menstrual cycle. This tightly controlled system disturbed in endometrial hyperplasia carcinomas a series changes initiate promote towards phenotype. These can be subdivided into discrete steps, involving activation oncogenes, inactivation tumour suppressor genes, deregulation cell cycle regulators or other proteins involved invasion progression. Immunohistochemical expression different biomarkers such as hormone receptor status (ER, PR), proliferation associated indices (PCNA, MIB1), oncogene (c-erbB-2), gene products (pRb, p53 protein), related (cyclin D1, cyclin E, p21/WAF1), anti-apoptotic protein (bcl-2), adhesion molecule (CD44s), proteolytic enzyme (cathepsin D), heat shock (hsp27) metallothionein (MT) has shown contribution these molecules carcinogenesis independent manner an early late event. In addition, seem correlated with differentiation myometrial invasion, therefore could considered indicators biological behaviour carcinoma. Furthermore, interrelationships markers show genetic dysregulations implicated control differentiation, thereby multistep process carcinogenesis.