Mammaglobin B expression in human endometrial cancer

摘要: Mammaglobin B (MGB-2) is an uteroglobin gene family member recently found highly differentially expressed in ovarian cancer by expression profiling. To evaluate its potential as a novel endometrial biomarker, this study we quantified and compared MGB-2 at messenger RNA protein levels tumors (endometrioid [EEC]) with different grades of differentiation. was evaluated real-time polymerase chain reaction (PCR) immunohistochemistry (IHC) fresh frozen biopsies paraffin-embedded tissues derived from total 70 patients including 50 primary EEC 20 normal endometria (NECs). High were detected 10 11 G1 cases (91%), 16 17 G2 (94%), 6 22 G3 (27%) PCR. In contrast, cells low to negligible PCR (P = 0.002 vs NEC). Well- moderately differentiated EECs overexpressed significant higher when NECs < 0.01). Pairwise differences between both for relative values also statistically (G2 P 0.001, 0.016). 31 (86%) 36 0 5 atrophic NEC controls, while seven eight (88%) the proliferative/secretory/hyperplastic focally IHC. EEC, particularly well- tumors, may represent molecular marker EEC.