Molecular and Pathologic Aspects of Endometrial Carcinogenesis
作者： Jonathan L. Hecht , George L. Mutter
关键词: Carcinogenesis 、 Pathology 、 Aneuploidy 、 Mutation 、 Endometrial cancer 、 Clear cell 、 Cancer 、 PTEN 、 Carcinoma 、 Medicine
摘要: Endometrial cancer is the most common gynecological malignancy, with 41,000 new cases projected in United States for 2006. Two different clinicopathologic subtypes are recognized: estrogen-related (type I, endometrioid) and non-estrogen-related types II, nonendometrioid such as papillary serous clear cell). The morphologic differences these cancers mirrored their molecular genetic profile type I showing defects DNA-mismatch repair mutations PTEN, K-ras, beta-catenin, II aneuploidy p53 mutations. This article reviews aspects of endometrial carcinogenesis progression. We will define precursor lesion endometrioid role genetics estrogen its
jco.org参考文章(109)
David E. MacCallum, Ted R. Hupp, Induction of p53 Protein as a Marker for Ionizing Radiation Exposure In Vivo DNA Repair Protocols. ,vol. 113, pp. 583- 589 ,(1999) , 10.1385/1-59259-675-4:583
Marian S. Blazes, Kathleen R. Cho, Steven I. Wang, Ramon Parsons, Shikha Bose, Lora Hedrick Ellenson, Hironori Tashiro, Jing Li, Rong Wu, Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Research. ,vol. 57, pp. 3935- 3940 ,(1997)
Andrew Berchuck, John I. Risinger, Patrice Watson, Henry T. Lynch, Jeff Boyd, Matthew F. Kohler, Genetic instability of microsatellites in endometrial carcinoma. Cancer Research. ,vol. 53, pp. 5100- 5103 ,(1993)
Andrew Berchuck, John I. Risinger, J. Carl Barrett, A. Kate Hayes, PTEN/MMAC1 Mutations in Endometrial Cancers Cancer Research. ,vol. 57, pp. 4736- 4738 ,(1997)
Andrew Berchuck, John I. Risinger, P. Andrew Futreal, Rex C. Bentley, G. Larry Maxwell, J. Carl Barrett, Heather Shaw, Curtis Gumbs, Mutation of the PTEN Tumor Suppressor Gene in Endometrial Hyperplasias Cancer Research. ,vol. 58, pp. 2500- 2503 ,(1998)
Setsuo Hirohashi, Takeshi Fukuchi, Shiro Nozawa, Michiie Sakamoto, Hitoshi Tsuda, Keiji Maruyama, β-Catenin Mutation in Carcinoma of the Uterine Endometrium Cancer Research. ,vol. 58, pp. 3526- 3528 ,(1998)
John I. Risinger, Olga Aprelikova, Tricia Patterson, G. Larry Maxwell, G. Larry Maxwell, J. Carl Barrett, G. V.R. Chandramouli, Amir A Jazaeri, Andrew Berchuck, Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancer Cancer Research. ,vol. 63, pp. 6- 11 ,(2003)
George L. Mutter, Anna S. Jovanovic, Kevin A. Boynton, Uteri of Women with Endometrial Carcinoma Contain a Histopathological Spectrum of Monoclonal Putative Precancers, Some with Microsatellite Instability Cancer Research. ,vol. 56, pp. 1917- 1921 ,(1996)
Gregory S. Buzard, Osamu Tanizawa, Alan O. Perantoni, Jerry M. Rice, Takayuki Enomoto, Hiroshi Miki, Masaki Inoue, K-ras activation in premalignant and malignant epithelial lesions of the human uterus. Cancer Research. ,vol. 51, pp. 5308- 5314 ,(1991)
Yo Kato, Hong Ouyang, Akira Horii, Tadayoshi Abe, Toni Furukawa, The BAX gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium. Clinical Cancer Research. ,vol. 4, pp. 1071- 1074 ,(1998)