Synthesis and biological evaluation of highly functionalized dispiro heterocycles
作者： Anshu Dandia , Anuj K. Jain , Ashok K. Laxkar
DOI: 10.1039/C3RA00170A
关键词: Antimicrobial 、 Organic chemistry 、 Carbon-13 NMR 、 Broth microdilution 、 Isatin 、 Cycloaddition 、 Biological evaluation 、 Sarcosine 、 Stereoselectivity 、 Chemistry 、 General chemistry 、 General Chemical Engineering
摘要: A series of highly functionalized dispiro[3H-indole-3,2′-pyrrolidine-3′,3′′-piperidine]-2(1H),4′′-dione derivatives have been synthesized in good to excellent yields by one pot three-component 1,3-dipolar cycloaddition reaction substituted isatin, sarcosine and 1-methyl-3,5-bis[(E)-arylidene]piperidin-4-one with high degree chemo-, regio- stereoselectivity. The structure relative stereochemistry cycloadducts were confirmed single crystal X-ray diffraction as well the help 1H, 13C NMR spectroscopic techniques. All compounds subjected vitro antimicrobial activity against various bacteria fungi using broth microdilution method antitubercular was carried out Mycobacterium tuberculosis H37Rv strain Lowenstein–Jensen medium. Some emerged antimicrobials reasonable antituberculars compared standard drugs.
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