Epigenetic changes at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms tumorigenesis.
作者： K. Okamoto , I. M. Morison , T. Taniguchi , A. E. Reeve
关键词: DNA methylation 、 Allele 、 Imprinting (psychology) 、 Genomic imprinting 、 Wilms' tumor 、 Carcinogenesis 、 Epigenetics 、 Endocrinology 、 Biology 、 Cancer research 、 Population 、 Internal medicine
摘要: Relaxation of imprinting at the insulin-like growth factor II (IFG-II)/H19 locus is a major mechanism involved in onset sporadic Wilms tumor and several other embryonal tumors. The high prevalence histologically abnormal foci kidney adjacent to tumors suggests that tumor-predisposing genetic/epigenetic lesion might also be found frequency tumor-bearing kidneys. Focusing on with relaxation IFG-II imprinting, we determined epigenetic change IFG-II/H19 kidney. In all kidneys these tumors, detected substantial mosaicism for population cells biallelic H19 methylation, regardless whether patient had syndrome or not. proportion epigenetically modified among “normal” tissue indicates error occurred very early development, before tumor. Not only does this suggest event occurs within first few days but it may represent one end spectrum overgrowth disorders characterized by mosaic locus.
core.ac.uk
harvard.edu
jstor.org 
sci-hub.se 参考文章(30)
C. T. Caskey, A. I. Edwards, H. A. Hammond, A. Civitello, DNA typing and genetic mapping with trimeric and tetrameric tandem repeats. American Journal of Human Genetics. ,vol. 49, pp. 746- 756 ,(1991)
A E Reeve, S A Sih, A M Raizis, A P Feinberg, Loss of allelic heterozygosity at a second locus on chromosome 11 in sporadic Wilms' tumor cells. Molecular and Cellular Biology. ,vol. 9, pp. 1799- 1803 ,(1989) , 10.1128/MCB.9.4.1799
Marja J. C. Steenman, Shirley Rainier, Craig J. Dobry, Paul Grundy, Isabelle L. Horon, Andrew P. Feinberg, Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour Nature Genetics. ,vol. 7, pp. 433- 439 ,(1994) , 10.1038/NG0794-433
Timothy H. Bestor, Benjamin Tycko, Creation of genomic methylation patterns. Nature Genetics. ,vol. 12, pp. 363- 367 ,(1996) , 10.1038/NG0496-363
Sharon Zemel, Marisa S. Bartolomei, Shirley M. Tilghman, Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2. Nature Genetics. ,vol. 2, pp. 61- 65 ,(1992) , 10.1038/NG0992-61
Philip A. Leighton, Robert S. Ingram, Jonathan Eggenschwiler, Argiris Efstratiadis, Shirley M. Tilghman, Disruption of imprinting caused by deletion of the H19 gene region in mice Nature. ,vol. 375, pp. 34- 39 ,(1995) , 10.1038/375034A0
Maxwell P. Lee, Ren-JuHu Hu, Laura A. Johnson, Andrew P. Feinberg, Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements. Nature Genetics. ,vol. 15, pp. 181- 185 ,(1997) , 10.1038/NG0297-181
Anthony E. Reeve, Michael R. Eccles, Richard J. Wilkins, Graeme I. Bell, Lynn J. Millow, Expression of insulin-like growth factor-II transcripts in Wilms' tumour Nature. ,vol. 317, pp. 258- 260 ,(1985) , 10.1038/317258A0
Lian-Yu Chao, Vicki Huff, Gail Tomlinson, Vincent M. Riccardi, Louise C. Strong, Grady F. Saunders, Genetic mosaicism in normal tissues of Wilms' tumour patients. Nature Genetics. ,vol. 3, pp. 127- 131 ,(1993) , 10.1038/NG0293-127
T. Taniguchi, M. J. Sullivan, O. Ogawa, A. E. Reeve, Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 2159- 2163 ,(1995) , 10.1073/PNAS.92.6.2159