Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment.

摘要: Lung carcinogenesis is a complex process involving the acquisition of genetic mutations that confer cancer development and malignant phenotype, critically linked to apoptosis resistance, unregulated proliferation, invasion, metastasis, angiogenesis. Epithelial mesenchymal transition (EMT) in an host environment with deregulated inflammatory response impairs cell-mediated immunity permits progression. Given immunosuppressive tumor environment, strategies reverse these events by stimulating immune responses are important area investigation. Cyclooxygenase 2 (COX-2) its downstream signaling pathways potential targets for lung chemoprevention therapy. Clinical trials underway evaluate COX-2 inhibitors as adjuvants chemotherapy patients determine efficacy prevention bronchogenic carcinoma. The understanding molecular mechanisms involved inflammation provide insight new drug target reversible, non-mutational treatment cancer.