Risk Factors for Candidemia in Patients with Acute Lymphocytic Leukemia

摘要: Between 1983 and 1987 the overall incidence of candidemia at Institut Gustave Roussy, a tertiary care referral hospital for patients with cancer, increased from 0.1% (7 6,801) to 0.32% (24 7,515) (P = .009). Because acute lymphocytic leukemia (ALL) was most common underlying disease in candidemia, risk factors were analyzed this subset patients. A case-control study comparing eight ALL who had 18 control revealed that previous bacteremia, prolonged neutropenia, fever, administration antimicrobial agents, treatment multiple relatively high concentration Candida organisms stool significant candidemia. In logistic regression analysis, however, only receipt vancomycin and/or imipenem identified as an independent factor Further analysis showed promoted proliferation gastrointestinal tract associated