Development of Local Circuit Connections to Hilar Mossy Cells in the Mouse Dentate Gyrus.
作者： Yulin Shi , Steven F. Grieco , Todd C. Holmes , Xiangmin Xu
DOI: 10.1523/ENEURO.0370-18.2019
关键词: Excitatory postsynaptic potential 、 Biology 、 Neuroscience 、 Local circuit 、 Dentate gyrus 、 Biological neural network 、 Hippocampal formation 、 Inhibitory postsynaptic potential 、 Hippocampus 、 Photostimulation
摘要: Hilar mossy cells in the dentate gyrus (DG) shape firing and function of hippocampal circuit. However, neural circuitry providing afferent input to is incompletely understood, little known about development these inputs. Thus, we used whole-cell recording laser scanning photostimulation (LSPS) characterize developmental trajectory local excitatory inhibitory synaptic inputs mouse hippocampus. were targeted by visualizing non-red fluorescent hilus GAD2-Cre; Ai9 mice that expressed tdTomato GAD+ neurons, confirmed post hoc morphological characterization. Our results show at postnatal day (P)6-P7, received more from neurons proximal CA3 versus those DG. In contrast, P13-P14 P21-P28, largest source originated DG cells, while strength hilar declined. A trend was also evident for Overall P6-P7 weak, cell layer predominated P21-P28. The excitation inhibition peaked decreased slightly older P21-P28 mice. Together, data provide new detailed information on connectivity suggests mechanisms through which changes circuit their physiology vulnerability injury during periods.
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