From Transcript to Protein

摘要: A lot of exciting new data were presented during the workshop and it is clear that considerable progress being made in unravelling mechanisms involved RNA maturation, transport, translation. Both genetic biochemical approaches continue to identify genes gene products mRNA formation function are helping characterize ways which specific sequences structures recognized. We can anticipate a very detailed description factors polyadenylation, splicing, export, translation, stability emerge over next few years. This work on basic reaction should also pave way better understanding posttranscriptional regulatory events controlling expression development differentiation. Several presentations illustrated importance studies for molecular medicine particular strategies employed by viral pathogens. By continuing study how viruses such as HIV, influenza, picornaviruses subvert translation machineries, more important information will about these processes act cellular RNAs uninfected cells.Another interesting theme emerged was growing impact large scale sequencing projects currently underway utility rapidly expanding sequence databases. Here we confidently predict future field, most other areas biology, benefit greatly from resources. The identification cloning be simplified, structure/function comparisons homologous proteins different species offer insights into processing transport.However, despite obvious advances reported workshop, many cases underlined just much remains learned aspects its regulation. For example, C. Milstein, showing in-frame stop codons recognized nucleus mechanism apparently independent translational machinery causes an inhibition demonstrate major gaps remain our functional mRNAs produced. similar conclusion drawn unexpected discovery diversity structure spliceosomes J. Steitz. Juan March Workshop possibilities field collaborations between disciplines genetics, biochemistry, virology. It this now extends cell shown talks transport macromolecules out nuclear organization. challenge involve defining transitory steps make well relating obtained vitro analyses with take place living cell.