Extracapsular Lymph Node Involvement Differs Between Squamous Cell and Adenocarcinoma of the Esophagus
作者： Ralf Metzger , Uta Drebber , Stephan E. Baldus , Stefan P. Mönig , Arnulf H. Hölscher
DOI: 10.1245/S10434-008-0248-9
关键词: Esophagus 、 Surgical oncology 、 Oncology 、 Lymph node 、 Medicine 、 Gastroenterology 、 Lymph 、 Esophageal cancer 、 Adenocarcinoma 、 Confidence interval 、 Neoadjuvant therapy 、 Internal medicine
摘要: There is increasing evidence regarding extracapsular lymph node involvement (LNI) as a prognostic factor for recurrence and poor prognosis in gastrointestinal malignancies. The aim of this study was to assess the prevalence impact LNI patients with resected esophageal cancer, comparing adenocarcinoma (AC) squamous cell carcinoma (SCC). Between 1997 2006, 243 consecutive cancer without neoadjuvant therapy (103 SCC, 140 AC) were studied. A total 738 metastases reexamined. Survival analyzed according intra- LNI. Median survival 13 months [range 11–14 months, 95% confidence interval (CI)] compared 28 (21–34 CI) those intracapsular alone (p = 0.017). Node-positive AC showed 66% 35% SCC < 0.001). number nodes frequency pN1 cases comparable between SCC. However infiltrated LN significantly 0.005) higher (median 5) 3). We conclude that an independent negative which occurs more frequently than
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