Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesis.

摘要: Purpose The ocular fundi of many patients with membranoproliferative glomerulonephritis type II (MPGN-II) are characterised by the presence deposits within Bruch's membrane that resemble drusen, hallmark lesions associated age-related macular degeneration (AMD). Glomerulonephritis (GN)-associated drusen appear at a younger age, however, than do in individuals AMD. In light recent evidence immune-mediated events participate biogenesis and AMD, we examined structure composition eyes obtained from human donors two distinct glomerulopathies, both which involve complement deposition glomeruli. These features were compared those clinically documented Methods Eyes diagnosed membranous post-streptococcal GN, respectively, analysed histochemically, immunohistochemically ultrastructurally. Results Subretinal pigment epithelial (RPE) types GN numerous indistinguishable, structurally compositionally, GN-associated exhibit sudanophilia, bind filipin, react antibodies directed against vitronectin, C5 C5b-9 complexes, TIMP-3 amyloid P component. Drusen donor, but not reacted peanut agglutinin MHC class antigens IgG. ultrastructural characteristics these also identical AMD-associated drusen. Conclusions post-streptococcal/segmental generally similar to view data supporting involvement activation pathobiology further studies biological relationships between AMD diseases warranted.